Abstract
Pharmacokinetics and toxicity are two critical factors in the development and administration of anticancer drugs. Understanding the absorption, distribution, metabolism, and excretion (ADME) of anticancer drugs is essential for optimizing their therapeutic efficacy and minimizing adverse effects. Moreover, the toxicity of anticancer drugs, which can affect healthy tissues and organs, is a major concern in cancer treatment. This article reviews the pharmacokinetics and toxicity of commonly used anticancer drugs, explores the mechanisms underlying drug resistance, and discusses strategies to mitigate toxicity. We also highlight recent advances in pharmacokinetic modeling and personalized medicine for more effective and safer cancer therapies.
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