Abstract
Antiviral drugs play a pivotal role in the prevention and treatment of viral infections. Understanding their pharmacodynamics (PD) is essential to optimizing therapeutic efficacy, minimizing resistance, and guiding clinical dosing regimens. This critical review explores the PD principles of key classes of antiviral agents, including nucleoside analogs, protease inhibitors, and entry inhibitors. We discuss dose-response relationships, viral kinetics, resistance mechanisms, and current challenges in translating PD knowledge into clinical practice.
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