Abstract
Pharmacokinetic (PK) modeling plays a pivotal role in the development and clinical use of medications by describing how drugs are absorbed, distributed, metabolized, and excreted in the body. Mathematical models help predict drug concentrations over time and guide dose selection to optimize therapeutic outcomes. This article explores the principles of pharmacokinetic modeling, including compartmental and physiologically based models, and discusses its critical applications in individualized drug dosage optimization, especially in special populations such as pediatrics and patients with renal impairment.
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