The Role of Nanoparticles in Drug Solubilization and Delivery

Abstract

Nanoparticles (NPs) have emerged as a promising tool in the field of drug delivery due to their unique physicochemical properties. These properties include a high surface area to volume ratio, which facilitates the solubilization and controlled release of hydrophobic drugs. Nanoparticles can enhance the bioavailability of poorly soluble drugs, ensuring effective therapeutic outcomes. This article reviews the role of nanoparticles in drug solubilization, focusing on their applications in various drug delivery systems, including oral, injectable, and transdermal systems. Furthermore, it discusses the challenges associated with the stability, toxicity, and regulatory concerns surrounding the use of nanoparticles in drug delivery.