Advances in Drug Formulation for the Treatment of Alzheimer’s Disease

Abstract

Alzheimer’s disease (AD) represents a major global health challenge with no definitive cure currently available. Drug development efforts have increasingly shifted focus toward advanced formulation strategies to enhance drug efficacy, bioavailability, and blood-brain barrier (BBB) permeability. This article reviews recent innovations in drug formulation for Alzheimer's treatment, including nanoparticle-based delivery systems, intranasal administration, prodrug approaches, and polymeric micelles. These advancements aim to overcome pharmacokinetic limitations and improve patient outcomes. The integration of personalized medicine and disease-modifying therapies into formulation design offers promising avenues for the future of AD treatment.