Abstract
The human microbiome, a complex community of microorganisms residing in the human body, has been increasingly recognized for its profound impact on drug metabolism and pharmacology. This article explores the intricate relationship between the gut microbiota and pharmacokinetics, emphasizing its role in drug absorption, metabolism, and therapeutic efficacy. Understanding the microbiome's influence on drug responses can lead to personalized medicine strategies, improved drug safety, and novel therapeutic interventions. This review examines the mechanisms through which microbiota affects drug metabolism, highlights specific microbial enzymes involved, and discusses the implications for drug design and clinical pharmacology.
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