Abstract
Biodegradable nanoparticles have emerged as a promising approach in controlled drug delivery systems, improving therapeutic efficacy and minimizing side effects. This study explores the formulation, optimization, and characterization of poly(lactic-co-glycolic acid) (PLGA)-based nanoparticles encapsulating a model hydrophobic drug. Emphasis is placed on physicochemical parameters including particle size, zeta potential, encapsulation efficiency, and in-vitro drug release profiles. Analytical techniques such as dynamic light scattering (DLS), scanning electron microscopy (SEM), and UV-spectrophotometry were utilized for characterization. The results confirm that PLGA nanoparticles provide stable encapsulation and sustained drug release, demonstrating their potential as efficient carriers for targeted drug delivery.
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