Abstract
Pharmacokinetics (PK) plays a crucial role in determining the optimal drug dosing regimen for individual patients. Variability in pharmacokinetic parameters such as absorption, distribution, metabolism, and elimination often leads to significant differences in drug responses among patients. These differences can impact the efficacy and safety of medications, especially in those with comorbidities, elderly patients, or those on polypharmacy. This paper explores the various factors that contribute to pharmacokinetic variability, including genetic factors, age, gender, disease state, and drug-drug interactions, and how these influence drug dosing strategies. The review also discusses strategies to mitigate the impact of PK variability through personalized medicine, therapeutic drug monitoring, and dose adjustments.
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